منابع مشابه
Genetics: Alzheimer disease.
Informative genetic testing is currently available to only a small number of families with a history of early-onset (younger than 60 years of age) Alzheimer disease (AD). For these families, the benefits of genetic testing are limited and are mainly related to the individual’s perception of the psychological advantages of knowing whether or not he or she is predisposed to develop AD. There rema...
متن کاملThe Genetics of Alzheimer Disease
Family history is the second strongest risk factor for Alzheimer disease (AD) following advanced age. Twin and family studies indicate that genetic factors are estimated to play a role in at least 80% of AD cases. The inheritance of AD exhibits a dichotomous pattern. On one hand, rare mutations in APP, PSEN1, and PSEN2 virtually guarantee early-onset (,60 years) familial AD, which represents 5%...
متن کاملGenetics of Psychosis in Alzheimer Disease.
Psychosis occurs in approximately half of patients with Alzheimer disease (AD with psychosis, AD+P). AD+P patients have more rapid cognitive decline, greater behavioral symptoms, and higher mortality than do AD patients without psychosis. Studies in three independent cohorts have shown that psychosis in AD aggregates in families, with estimated heritability of 29.5 - 60.8%. These findings have ...
متن کاملThe Genetics of Alzheimer Disease: Back to the Future
Three decades of genetic research in Alzheimer disease (AD) have substantially broadened our understanding of the pathogenetic mechanisms leading to neurodegeneration and dementia. Positional cloning led to the identification of rare, disease-causing mutations in APP, PSEN1, and PSEN2 causing early-onset familial AD, followed by the discovery of APOE as the single most important risk factor for...
متن کاملThe role of genetics in alzheimer’s disease
Alzheimer's disease is a progressive neurological disorder that causes the brain to shrink (atrophy) and brain cells die. Alzheimer's disease is the most common cause of dementia and causes a decrease in thinking skills and social behaviors. Alzheimer's disease is more common in people over 65 years old. The risk of developing Alzheimer's disease and other types of dementia increases with age,...
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ژورنال
عنوان ژورنال: American Journal of Neuroradiology
سال: 2013
ISSN: 0195-6108,1936-959X
DOI: 10.3174/ajnr.a3545